| 生酮饮食治疗成人难治性癫癎的研究进展 |
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| 引用本文： | 尚丽,王曼,王开颜.生酮饮食治疗成人难治性癫癎的研究进展[J].中国临床神经科学,2013(6):691-698. |
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| 作者姓名： | 尚丽 王曼 王开颜 |
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| 作者单位： | [1]复旦大学附属华山医院神经内科,200040 [2]上海德济医院癫痫中心,200331 |
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| 摘 要： | 生酮饮食（KD）治疗儿童难治性癫癎（RE）已有近百年历史，其抗癫痫机制与抗癫癎药物的作用机制不同。近来出现改良的KD，并开始用于治疗成人RE，其有效率达41％，且与酮体水平不相关，而不良反应和儿童类似。
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| 关 键 词： | 生酮饮食 难治性癫癎 酮体 糖酵解抑制剂 哺乳类动物雷帕霉素靶蛋白 |
Research Progress of the Ketogenic Diet in the Treatment of Adults with Refractory Epilepsy |
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| SHANG Li^,WANG Man^,WANG Kai-yan.Research Progress of the Ketogenic Diet in the Treatment of Adults with Refractory Epilepsy[J].Chinese Journal of Clinical Neurosciences,2013(6):691-698. |
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| Authors: | SHANG Li^ WANG Man^ WANG Kai-yan |
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| Institution: | 1 1Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040;2 2Department of Epilepsy Center, Deji Hospital, Shanghai 200331, China |
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| Abstract: | The ketogenic diet（KD） has been used to treat children with refractory epilepsy（RE） for about one hundred years. The mechanisms of KD are different from antiepileptic drugs. Recently, the modified KD was used to treat adults with RE. Its efficiency was nearly 41%, which was independent of ketone body levels. Its side effects appeared similar to those encountered in children with RE. |
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| Keywords: | ketogenic diet refractory epilpsy ketone body glycolysis inhibitor mammaliantarget of rapamycin |
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