“真实世界”研究的产生背景、概念、方法及其在眼科的应用

“真实世界”研究（RWS）是起源于实用性的临床试验，属于药物流行病学的范畴。是基于临床真实的干预情况采取的一种非随机、开放性、不使用安慰剂的研究，因此其得出的结果具有很高的外部有效性。目前RWS已得到很多医学领域的重视，有些学科已经建立了较为完整的观察性队列、登记和管理型数据库。眼科学界对RWS设计的尝试才刚刚起步。笔者就RWS的背景、概念、方法以及在眼科的应用做一文献复习。

Background,conceptions, methodology of the Real-World Study and its application in ophthalmology

Real-World Study （RWS） is originated in the practical clinical trials, which belongs to the category of drug epidemiology. It is non-random, open, no placebo research, and based on the clinical actual situation and the emphasizing the external validity of the research results. The RWS has received a lot of attention and in some field of medicine, disease-specific observational cohort, registry and management database have been well-established. While the RWS in ophthahnology is just starting up. In this article, the background, concepts, methods of RWS and its application in ophthalmology were reviewed.