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Recent advances in gelatin-based therapeutics |
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| Authors: | Mari Carmen Echave Raquel Hernáez-Moya Leire Iturriaga José Luis Pedraz Rajamani Lakshminarayanan Alireza Dolatshahi-Pirouz |
| Affiliation: | 1. NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country UPV/EHU, Paseo de la Universidad 7, Vitoria-Gasteiz, Spain;2. Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria-Gasteiz, Spain;3. Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, Discovery Tower, Singapore;4. Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Graduate Medical School, Singapore;5. Center for Intestinal Absorption and Transport of Biopharmaceuticals, Technical University of Denmark, DTU Nanotech, Copenhagen, Denmark;6. Department of Dentistry – Regenerative Biomaterials, Radboud University Medical Center, Nijmegen, The Netherlands |
| Abstract: | Introduction: Biomaterials have provided a wide range of exciting opportunities in tissue engineering and regenerative medicine. Gelatin, a collagen-derived natural biopolymer, has been extensively used in regenerative medicine applications over the years, due to its cell-responsive properties and the capacity to deliver a wide range of biomolecules. Areas covered: The most relevant properties of gelatin as biomaterial are presented together with its main therapeutic applications. The latter includes drug delivery systems, tissue engineering approaches, potential uses as ink for 3D/4D Bioprinting, and its relevance in organ-on-a-chip platforms. Expert opinion: Advances in polymer chemistry, mechanobiology, imaging technologies, and 3D biofabrication techniques have expanded the application of gelatin in multiple biomedical research applications ranging from bone and cartilage tissue engineering, to wound healing and anti-cancer therapy. Here, we highlight the latest advances in gelatin-based approaches within the fields of biomaterial-based drug delivery and tissue engineering together with some of the most relevant challenges and limitations. |
| Keywords: | Biomaterial drug delivery gelatin regenerative medicine tissue engineering |