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Effect of fentanyl and vitamin B12 on abdominal pain in patients addicted to oral opium: A clinical trial |
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| Authors: | Narges Sherkatbazazan Shiva Moeinaddini Milad Ahmadi Gohari |
| Affiliation: | 1. Department of Emergency Medicine, Kerman University of Medical Sciences, Kerman, Iran;2. Department of Emergency Medicine, Rafsanjan University of Medical Sciences, Kerman, Iran;3. Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran |
| Abstract: | Background: Pain is a common complaint among patients referring to the emergency department. This study aimed at comparing the effect of fentanyl and vitamin B12 to decrease the abdominal pain in patients who are addicted to oral opium. Methods: This study conducted a double-blind randomized clinical trial on patients addicted to oral opium during a one-year period. The effects of fentanyl and vitamin B12 were compared for the relief of abdominal pain in such patients. Results: The 136 patients studied had a mean age of 47.77 ± 13.6 years (mean ± SD). There was a significant difference in mean pain severity at 10, 15, 30, 45, 60, and 120 min (P < .05). The mean pain severity in the fentanyl group was significant at 30 min compared to the earlier times and showed a decreasing trend in pain severity (P < .05). This decreasing trend was observed up to 120 min for the fentanyl + vitamin B12 group, which showed a significant difference between each time and the time preceding it (P < .05). Conclusions: The proper and permanent control of abdominal pain experienced by patients addicted to oral opium is essential. The combined use of fentanyl and vitamin B12 is effective in reaching this goal. |
| Keywords: | Abdominal pain fentanyl vitamin B12 opium |