Prehypertension in early versus late pregnancy |
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| Authors: | Jonathan Y. Rosner Megan Gutierrez Margaret Dziadosz Terri-Ann Bennett Cara Dolin Amelie Pham |
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| Affiliation: | 1. Division of Maternal Fetal Medicine, Department of OBGYN and Women’s Health, Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY, USA;2. Department of OBGYN, Saint Barnabas Medical Center, Livingston, NJ, USA;3. Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, NYU Langone Medical Center, NYU School of Medicine, New York, NY, USA;4. Department of Obstetrics and Gynecology, George Washington University School of Medicine and Health Science, Washington, DC, USA |
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| Abstract: | Introduction: Hypertensive disorders play a significant role in maternal morbidity and mortality. Limited data on prehypertension (preHTN) in pregnancy exist. We examine the risk of adverse outcomes in patients with preHTN in early (<20 weeks) versus late pregnancy (>20 weeks).Materials and methods: Retrospective cohort study of singleton gestations between August 2013 and June 2014. Patients were divided based on when they had the highest blood pressure in pregnancy, as defined per the Joint National Committee 7 (JNC-7). Groups were compared using χ2, Fisher’s exact, Student’s t-test, and Mann–Whitney U test with p?Results: There were 125 control, 95 early preHTN, 136 late preHTN, and 21 chronic hypertension (CHTN). Early preHTN had an increased risk of pregnancy-related hypertension (PRH) (OR 12.26, p?p?p?=?.02) compared with normotensive and decreased risk for PRH (OR 0.26, p?=?.02), and composite adverse outcomes (OR 0.379, p?=?.04) compared with CHTN. Compared with late preHTN, early preHTN had more PRH (OR 2.85, p?p?=?.04).Conclusions: Early prehypertension increases the risk of adverse obstetrical outcomes. Other than an increased risk of PRH, patients with late prehypertension have outcomes similar to normotensive women. |
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| Keywords: | Adverse outcomes hypertension pregnancy prehypertension |
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