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Disease of the Year: Differential Diagnosis of Uveitic Macular Edema
Authors:Aniruddha Agarwal  Francesco Pichi  Alessandro Invernizzi
Affiliation:1. Department of Ophthalmology, Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Chandigarh, India;2. Cleveland Clinic Abu Dhabi, Eye Institute, Abu Dhabi, United Arab Emirates.;3. Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, USA;4. Eye Clinic, Department of Biomedical and Clinical Science ‘Luigi Sacco’, Luigi Sacco Hospital, University of Milan, Milan, Italy;5. Department of Ophthalmology, Save Sight Institute, University of Sydney, Sydney, New South Wales, Australia
Abstract:Uveitic cystoid macular edema (UME) is an important cause of visual morbidity among patients with both infectious and non-infectious uveitis. UME may be associated in more than 30% cases of active uveitis. However, even patients with minimal features of intraocular inflammation may develop recurrent or chronic UME. Therefore, the evaluation and management of UME in patients with uveitis may be challenging. A number of vitreoretinal pathologies may result in UME and accumulation of fluid in the intra- or subretinal space. These need to be carefully distinguished from each other so that appropriate management can be initiated. All types of uveitis, including anterior uveitis (where the primary site of inflammation is not in the posterior segment) can present with UME. Other conditions such as diabetes, and surgery, can present with macular edema. This index review highlights various differential diagnoses of UME and provides illustrative case examples with multimodal imaging evaluation.
Keywords:Macular edema  optical coherence tomography  fluorescein angiography  CME  retinal thickness
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