阻塞性睡眠呼吸暂停低通气综合征患者日间嗜睡与清醒安静状态下动脉血氧饱和度的相关性研究

目的 探讨清醒安静状态下动脉血氧饱和度(SaO2)在阻塞性睡眠呼吸暂停低通气综合征(OSAS)患者合并日间嗜睡发病机制的作用.方法 回顾性收集2010年1至4月在华西医院睡眠医学中心就诊的OSAS患者410例,呼吸暂停低通气指数(AHI)≥5次/h,每例都详细地询问病史和自评Epworth嗜睡量表(ESS),并将OSA...

Relationship between excessive daytime sleepiness and oxygen saturation in obstructive sleep apnea-hypopnea syndrome

Objective To investigate polysomnographic determinants of excessive daytime sleepiness (EDS) and potential relationship in Chinese patients with obstructive sleep apnea-hypopnea syndrome (OSAS). Methods A total of 410 patients with obstructive sleep apnea-hypopnea syndrome were analyzed retrospectively who were obtained in Sleep medicine center of West China hospital from January to April in 2010. All of the patients with an apnea-hypopnea index (AHI) greater than 5 h-1 were evaluated using the Epworth Sleepiness Scale (ESS) and sleep disorders questionnaire. The patients who ESS score was more than 10 were defined as EDS; otherwise, the other was considered to without EDS. Results A total of 176 patients with EDS( ESS: 15 ± 3 ) and 234 without EDS ( ESS: 6 ± 3 ) were studied. Patients with EDS were slightly higher BMI (28 ±4 vs 26 ±4) and shorter REM sleep latency (99 ±65 vs 125 ±81 ) than patients without EDS. Furthermore, there were significant difference in awake SaO2, AHI, minimum SaO2,oxygen desaturation index and arousal index between EDS group were No-EDS group ( P ＜ 0. 001 ). There was a significant difference in waking SaO2 of severe OSAS between both groups. Conclusion Long-term chronic hypoxia already exists in severe OSAS patients with prominent sleepiness. Waking SaO2 may play a role as a predictor in evaluation and diagnosis in patients with OSAS.