不同时间窗经皮冠状动脉介入治疗对急性心肌梗死患者预后的影响

目的 比较急性心肌梗死(AMI)患者,不同时间窗行直接经皮冠状动脉介入治疗(PCI)后,对患者预后的影响.方法 我院2007年1月至2008年9月连续入院行直接PCI的AMI患者95例.按行直接PCI时间分为:AMI后A组(＜6 h)45例,B组(6～12 h)15例和C组(12～24 h)35例.分别比较A、B、C 3组的术后心衰发生率、总死亡率.于PCI后6个月行超声心动图检查,测定左室射血分数(LVEF)、左室舒张末期内径.结果 住院期间和随访期间,术后A组的心衰发生率(8.9%)、总死亡率(2.2%),均明显低于B组(13.3%与6.7%)、C组(34.3%与14.2%),B组明显低于C组,差异有统计学意义(P＜0.05).3组在术后6个月行超声心动图检查,A组LVEF(57.51±6.9)%明显高于B组(52.25±4.27)%、C组(47.75±6.86)%,差异有统计学意义(P＜0.05).A组左室舒张末期内径(45.9±4.2)mm明显低于B组(49.0±3.1)mm、C组(52.5±4.9)mm,差异有统计学意义(P＜0.05).结论 急性心肌梗死后行PCI术时间越早则患者心功能恢复越好,心衰发生率越低,左室重构越低,死亡率越低,改善左心功能和预后.

Abstract：

Objective To compare the prognostic effects of different time windows on initiating PCI (percutaneous coronary intervention)in AMI(acute myocardial infarction)patients.Methods Ninety-five AMI patients undergoing PCI were enrolled continuously from January 2007 to September 2008.According to the timing of direct PCI,the patients were divided into 3 groups:after AMI,＜ 6 h(Group A,n=45),6-12 h(Group B,n=45)and 12-24 h(Group C,n=35).Comparisons were made among these 3 groups in terms of the post-PCI incidence of heart failure and mortality.The left ventricular ejection fraction(LVEF)and left ventricular end-diastolic inside diameter(LVEDV)were measured by echocardiogram at Month 6.Results During the hospitalization and follow-up,Group A had a lower incidence of heart failure and mortality than Groups B and C.And Group B had a lower rate than Group C.The difference was significant (P＜0.05).Compared with LVEF(%)(52.25 ± 4.27)in Group B and LVEF(%)(47.75 ± 6.86)in Group C,LVEF(%)(57.51 ±6.9)in Group A were significantly improved on ECG at Month 6 months.LVEDV(mm)(45.89 ±4.23)in Group A were significantly lower than LVEDV(mm)(49.0 ±3.1)in Group B and LVEDV(mm)(52.46 ±4.9)in Group C.The differences were both statistically significant (P＜0.05).Conclusion An early time windows of initiating PCI in AMI patients can significantly improve the left ventricular functions and reduce the incidence of heart failure,left ventricular remodeling and the mortality rate.All these measures could improve left ventricular functions and prognosis.

Prognostic effects on percutaneous coronary intervention of different time windows in patients with acute myocardial infarction

Objective To compare the prognostic effects of different time windows on initiating PCI (percutaneous coronary intervention)in AMI(acute myocardial infarction)patients.Methods Ninety-five AMI patients undergoing PCI were enrolled continuously from January 2007 to September 2008.According to the timing of direct PCI,the patients were divided into 3 groups:after AMI,＜ 6 h(Group A,n=45),6-12 h(Group B,n=45)and 12-24 h(Group C,n=35).Comparisons were made among these 3 groups in terms of the post-PCI incidence of heart failure and mortality.The left ventricular ejection fraction(LVEF)and left ventricular end-diastolic inside diameter(LVEDV)were measured by echocardiogram at Month 6.Results During the hospitalization and follow-up,Group A had a lower incidence of heart failure and mortality than Groups B and C.And Group B had a lower rate than Group C.The difference was significant (P＜0.05).Compared with LVEF(%)(52.25 ± 4.27)in Group B and LVEF(%)(47.75 ± 6.86)in Group C,LVEF(%)(57.51 ±6.9)in Group A were significantly improved on ECG at Month 6 months.LVEDV(mm)(45.89 ±4.23)in Group A were significantly lower than LVEDV(mm)(49.0 ±3.1)in Group B and LVEDV(mm)(52.46 ±4.9)in Group C.The differences were both statistically significant (P＜0.05).Conclusion An early time windows of initiating PCI in AMI patients can significantly improve the left ventricular functions and reduce the incidence of heart failure,left ventricular remodeling and the mortality rate.All these measures could improve left ventricular functions and prognosis.