| 依科源牌美容胶囊安全性评价试验 |
| |
| 引用本文： | 傅颖,梅松,陈建国,来伟旗,王茵.依科源牌美容胶囊安全性评价试验[J].职业与健康,2006,22(8):580-582. |
| |
| 作者姓名： | 傅颖 梅松 陈建国 来伟旗 王茵 |
| |
| 作者单位： | 浙江省医学科学院保健食品研究所,杭州市,310013 |
| |
| 摘 要： | 目的为依科源牌美容胶囊安全性评价提供毒理学依据。方法采用急性毒性试验,小鼠骨髓细胞微核试验,Ames试验,小鼠精子畸形试验和大鼠30 d喂养试验进行检测。结果依科源牌美容胶囊对雌雄性小鼠和雌雄性大鼠经口LD50均大于10.0 g/kg,属实际无毒级。3项致突变试验均未显示出突变性,对大鼠30 d喂养试验各项指标均未见明显毒性,大鼠30d喂养试验无作用剂量为3.67 g/kg。结论依科源牌美容胶囊3个阶段毒性试验结果均未表现出明显毒性。
|
| 关 键 词： | 依科源牌美容胶囊 急性毒性 遗传毒性 30 d喂养试验 |
| 文章编号： | 1004-1257（2006）08-0580-03 |
| 收稿时间： | 2005-07-25 |
| 修稿时间： | 2005年7月25日 |
Evaluation of the Safety of Yikeyuan Beauty Capsule |
| |
| FU Ying , MEI Song, CHEN Jian-guo ,et al..Evaluation of the Safety of Yikeyuan Beauty Capsule[J].Occupation and Health,2006,22(8):580-582. |
| |
| Authors: | FU Ying MEI Song CHEN Jian-guo |
| |
| Institution: | Zhejiang Academy of Medical Sciences, Hangzhou , 310013, China |
| |
| Abstract: | Objective]To provide toxicological basis for the safety evaluation of Yikeyuan beauty capsule.Methods]Acute toxicity test,marrow micronucleus test on mice,Ames test,sperm malformation test and 30 days' feeding test were carried out for the detection.(Results])Oral LD_(50) of Yikeyuan beauty capsule on male and female mice were above 10.0 g/kg with no toxicity.All the three mutagenicity tests showed no mutagenicity;no obvious toxicity was found in all the indexes of the 30 days' feeding test,the ineffective dose of which was 3.67 g/kg.Conclusion]No significant toxicity was found in the three stages of toxicological tests for Yukeyuan beauty capsule. |
| |
| Keywords: | Yikeyuan beauty capsule Acute toxicity Inherited toxicity 30 days' feeding test |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
