| 辐照致弱血吸虫尾蚴在小动物中诱导的保护力及其影响因素 |
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| 引用本文： | 张素华,吴海玮. 辐照致弱血吸虫尾蚴在小动物中诱导的保护力及其影响因素[J]. 国际医学寄生虫病杂志, 2008, 35(2) |
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| 作者姓名： | 张素华 吴海玮 |
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| 作者单位： | 1. 210029,南京,江苏省现代病原重点实验室,南京医科大学病原生物学系;225001,扬州,江苏省苏北人民医院临床检测中心
2. 江苏省现代病原重点实验室,南京医科大学病原生物学系,南京,210029 |
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| 摘 要： | 动物免疫/攻击感染实验显示,辐照致弱尾蚴在多种动物模型能诱导出高水平保护力.与辐照致弱曼氏血吸虫(Schistosoma mansoni,S.m)尾蚴诱导产生稳定高保护力相比,辐照致弱日本血吸虫(Schistosoma japonicum,S.j)尾蚴在小动物(特别是小鼠)中诱导产生的保护力常不稳定,可能与尾蚴的生物学特性、免疫程序、实验条件以及所采用的动物品系等因素有关,目前尚缺乏公认的能对其产生稳定高保护力的小鼠品系.该文就辐照致弱尾蚴在小动物尤其是小鼠诱导产生的抗感染保护力,特别是其影响因素作一综述,为构建S.j辐照致弱尾蚴的高保护力动物模型提供参考.
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| 关 键 词： | 血吸虫 致弱尾蚴 疫苗 保护力 鼠系 |
The protective effects and relevant factors of vaccination with radiation-attenuated schistosome cercariae in small animals |
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| ZHANG Su-hua,WU Hai-wei. The protective effects and relevant factors of vaccination with radiation-attenuated schistosome cercariae in small animals[J]. International JOurnal of Medical Parasitic Diseases, 2008, 35(2) |
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| Authors: | ZHANG Su-hua WU Hai-wei |
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| Abstract: | Experiments in animals indicated that attenuated cercariae could induce high level of protection to schistosome infection.Compared with Schistosoma mansoni(S.m),the levels of protection in mouse induced by Schistosoma japonicum(S.j)attenuated cercariae were variable,which may be related with several factors,such as the biological features of cercariae,the immunization procedure,experimental environment,animal strains,etc.There is still no well-established mice model that would show stable protection after S.j attenuated cercanae vaccination.Hence,we reviewed here the protective effects induced by vaccination with radiation-attenuated schistosome cercariae in small animals,especially the relevant influential factors. |
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| Keywords: | Schistosome Attenuated cercariae Vaccine Protection Mouse species |
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