| 肺癌患者化疗前后血清NSE、IGF-Ⅱ和TNF-α检测的临床意义 |
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| 引用本文： | 吉亚君,杨成喜,卞宝祥,宋子焱.肺癌患者化疗前后血清NSE、IGF-Ⅱ和TNF-α检测的临床意义[J].放射免疫学杂志,2008,21(2):118-119. |
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| 作者姓名： | 吉亚君 杨成喜 卞宝祥 宋子焱 |
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| 作者单位： | 江苏省连云港市第一人民医院肿瘤科,222002 |
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| 摘 要： | 目的：探讨肺癌患者化疗前后血清NSE、IGF-Ⅱ和TNF-α含量的变化。方法：应用放射免疫分析检测38例肺癌患者化疗前后血清NSE、IGF-Ⅱ和TNF-α含量，并与35名正常健康人作比较。结果：肺癌患者在化疗前血清中NSE、IGF-Ⅱ和TNF-α水平均非常显著地高于正常人组（P〈0．01），化疗后6个月在未复发的25例中明显下降接近于正常人组，而复发的5例，其数值又回升至化疗前水平（P〈0．05）。结论：检测肺癌患者血清NSE、IGF-ⅡI和TNF-α含量的变化可作为诊断和疗效观察的参考。
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| 关 键 词： | 肺癌 神经元特异性烯醇化酶(NSE) 胰岛素样生长因子-Ⅱ(IGF-Ⅱ) 肿瘤坏死因子-α(TNF-α) |
| 修稿时间： | 2008年2月26日 |
Clinical Significance of Determination of Changes of Serum NSE,IGF-Ⅱand TNF-α Levels After Chemotherapy jn Patients with Lung Cancer |
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| Ji Yajun,Yang Chengxi,Bian Baoxiang,et al..Clinical Significance of Determination of Changes of Serum NSE,IGF-Ⅱand TNF-α Levels After Chemotherapy jn Patients with Lung Cancer[J].Journal of Radioimmanology,2008,21(2):118-119. |
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| Authors: | Ji Yajun Yang Chengxi Bian Baoxiang |
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| Abstract: | Objective To detect the changes of serum NSE, IGF - Ⅱ and TNF - α levels after chemotherapy in patients with lung cancer. Methods Serum NSE, IGF - Ⅱ and TNF -α levels were determined with RIA in 38 patients with lung cancer both before and after chemotherapy as well as in 35 controls. Results Before chemotherapy, serum NSE, IGF - Ⅱ and TNF - α levels in the patients were significantly higher than those in the controls （P 〈 0.01 ） , After chemotherapy, in 25 cases without recurrence at 6 months, the levels were remained dropped markedly and approached those in controls. However in the 5 patients with recurrence, the levels increased again, approaching those before chemotherapy. Conclusion Serum levels of NSE, IGF - Ⅱ and TNF - α might be useful for diagnosis and predicting therapeutic effects after chemotherapy in patients with lung cancer. |
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| Keywords: | lung cancer neuron specific enolace （NSE） insulin -like growth factor- Ⅱ （IGF - Ⅱ ） tumor necrosis factor - α （TNF - α） |
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