Inhibition of 3,3',4,4',5-Pentachlorobiphenyl-Induced Chicken Embryotoxicity by 2,2',4,4',5,5'-Hexachlorobiphenyl |
| |
| Authors: | ZHAO, FENG MAYURA, KITTANE KOCUREK, NATHAN EDWARDS, JOHN F. KUBENA, LEON F. SAFE, STEPHEN H. PHILLIPS, TIMOTHY D. |
| |
| Affiliation: | *Department of Veterinary Anatomy and Public Health Texas 77843-4458 !["{dagger}"]("/math/dagger.gif") Department of Veterinary Pathobiology, Texas A&M University, College Station Texas 77843-4458 !["{ddagger}"]("/math/Dagger.gif") U.S.D.A. Agricultural Research Service, College Station Texas 77843 Department of Veterinary Physiology and Pharmacology Texas 77843-4458 Received November 9, 1995; accepted September 10, 1996 |
| |
| Abstract: | 3,3',4,4',5-Pentachlorobiphenyl (pentaCB) caused a dose-dependentinduction of chicken embryolethality, malformations, edema,and liver lesions at doses ranging from 0.5 to 12.0 µg/kg.In contrast, no embryotoxicity was observed after treatmentwith 10, 25, or 50 mg/kg 2,2',4,4',5,5'-hexaCB. In eggs cotreatedwith 2.0 µ/kg, 3,3',4,4',5-pentaCB plus 10, 25, or 50mg/kg 2,2',4,4',5,5'-hexaCB, there was significant protectionfrom 3,3',4,4',5-pentaCB-induced embryo malformations, edema,and liver lesions, whereas no inhibition of embryolethalitywas observed. These results further extend the response-specificnonadditive interactions of binary mixtures of polychlorinatedbiphenyls (PCBs) and should be considered in the developmentof approaches for hazard assessment of PCB mixtures and relatedcompounds. |
| |
| Keywords: | |
| 本文献已被 Oxford 等数据库收录！ |
|
