Screening for Hepatitis B Virus DNA in Serum of Organ Donors and Renal Transplant Recipients期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Screening for Hepatitis B Virus DNA in Serum of Organ Donors and Renal Transplant Recipients

Authors:	M.?Miédougé author-information" > author-information__contact u-icon-before" > mailto:miedouge.m@chu-toulouse.fr" title=" miedouge.m@chu-toulouse.fr" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,L.?Rostaing,J.?M.?Mansuy,K.?Sandres-Sauné,F.?Boudet,J.?Izopet

Affiliation:	1.Laboratoire de Virologie, H?pital Purpan,CHU Toulouse,Toulouse Cedex 9,France;2.Unité de Transplantation d'Organes, H?pital Rangueil,CHU Toulouse,Toulouse Cedex 9,France;3.Coordination des Prélèvements d'Organes, H?pital Purpan,CHU Toulouse,Toulouse Cedex 9,France

Abstract:	In order to determine the impact of screening potential organ donors for hepatitis B virus DNA using a standardized test, the serum of 145 donor candidates was tested. All of the candidates were negative for hepatitis B virus DNA, but the status of one donor was doubtful for hepatitis B virus surface antigen and seven donors tested positive for hepatitis B virus core antibody without hepatitis B virus surface antigen. Nine transplant recipients tested positive for hepatitis B virus surface antibody; they were given kidneys from the donor with a doubtful hepatitis B virus surface antigen result and from four of the seven donors who tested positive for hepatitis B core antibody. Follow-up revealed no case of hepatitis B transmission. In this study, screening for hepatitis B virus DNA was useful and did not lead to donor organ shortage. Patients with hepatitis B virus surface antibodies can safely be given kidneys from donors who are positive for hepatitis B core antibody but negative for hepatitis B virus DNA. Electronic Publication

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