Zur Acetylierung von Spironolacton,Canrenon und 2-Methylencanrenon |
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| Authors: | Klaus G rlitzer,Peter Moormann,Kunhard Pollow,Michael Schaffrath |
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| Affiliation: | Klaus Görlitzer,Peter Moormann,Kunhard Pollow,Michael Schaffrath |
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| Abstract: | Acetylation of Spironolactone, Canrenone, and 2-Methylene Canrenone Reaction of the title compounds with acetic anhydride and acetyl chloride yields the 3,5-dien-3-yl acetate 2 the isomeric 2,4,6- and 3,5,7-trien-3-yl acetates 3 and 4 as well as the 2,4,6,8(14)-tetraen-3-yl acetate 7 . The 2α-methyl-8,14-didehydro-canrenone ( 9 ) is obtained by hydrolysis of 7 . Binding affinities of 7 and 9 to hormone receptors as well as serum proteins (SHBG, CBG) are investigated. The compounds are inactive. |
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