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Short tandem repeat polymorphism linkage studies in a new family with X-linked mental retardation (MRX20)
Authors:Alice Lazzarini  Edward S. Stenroos  Thomas Lehner  Vershon McKoy  Bert Gold  Michael K. McCormack  Cheryl S. Reid  Jurg Ott  William G. Johnson
Abstract:A family with X-linked recessive mental retardation (XLMR) without other obvious manifestations (MRX20) was studied with 14 short tandem repeat polymorphism (STRP) markers. Two-point lod scores above 3 were obtained with DXS1003, DXYS1, DXS3, and DXS458. A multipoint lod score of 4.25 was obtained with peak at DXS1003. Recombination events identify a 55.6 cM interval between DXS1068 and DXS454, while a one unit support interval identifies 40 cM between MAOA and DXS458. © 1995 Wiley-Liss, Inc.
Keywords:mental retardation  X-linked mental retardation  MRX  pericentromeric X
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