Inclusion of ALKBH5 as a candidate gene for the susceptibility of autoimmune thyroid disease |
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| Affiliation: | 1. Department of Pneumonology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland;2. Department of Respiratory Medicine, Allergology and Pulmonary Oncology, Poznan University of Medical Sciences, Poznan, Poland;3. Department of Epidemiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland;4. Department of Cardiac Anaesthesia and Intensive Care, Silesian Centre for Heart Diseases in Zabrze, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland;5. Faculty of Science and Technology, University of Silesia in Katowice, 75 Pułku Piechoty 1A, 41-500, Chorzów, Poland;6. Department of Swimming and Water Rescue, Institute of Sport Science, The Jerzy Kukuczka Academy of Physical Education, Katowice, Poland;7. Department of Anaesthesiology and Intensive Care, Medical University of Silesia, Katowice, Poland;1. Department of Gastroenterology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland;2. Department of Radiology, Medical University of Bialystok, Bialystok, Poland;3. Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, Poland;1. Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;2. Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran;1. Department of Experimental Oncology, Institute of Oncology and Radiology of Serbia, Belgrade, Serbia;2. Department of Biomedical Sciences, University of Hull, Hull, UK;1. Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran;2. Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran;3. Institute of Population Health Sciences, Barts and the London School of Medicine, Queen Mary University of London, United Kingdom;4. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran |
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| Abstract: | PurposeRNA demethylase AlkB homolog 5 (ALKBH5) gene is pivotal in N6-methyladenosine (m6A) modification. Therefore, this study aimed to explore the potential relationship between polymorphisms of ALKBH5 gene and the development of autoimmune thyroid disease (AITD).Material and methodsA case-control study of 979 AITD patients, including 620 Graves' disease (GD) and 359 Hashimoto's thyroiditis (HT), and 732 normal controls of the Chinese Han population was performed using high-throughput sequencing (HiSeq) genotyping method for detecting 5 variants in ALKBH5 gene (rs12936694, rs2124370, rs4925144, rs8068517, and rs9913266). In addition, the associations between ALKBH5 single nucleotide polymorphisms (SNPs) and clinical phenotypes of AITD were investigated.ResultsCompared to normal controls, rs9913266 displayed significant differences in allele and genotype distributions in AITD and GD. rs12936694 also showed significantly different frequencies of alleles in AITD and GD. The link of these 2 loci polymorprhisms to AITD and GD also existed after adjusting for age and gender. When stratified by sex, the minor allele of rs9913266 was associated with the risk of female AITD and HT development before and after adjusting for age and gender. There was a significant association between rs8068517 locus and GD in females after adjusting for the confounders. Finally, we observed significant correlations of haplotypes CGACA and CAGCG to the susceptibility of AITD and GD.ConclusionsOur results provided evidence of association of polymorphisms in ALKBH5 gene with AITD, GD, and HT patients, and hence ALKBH5 might be the candidate gene for susceptibility to AITD. |
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| Keywords: | Polymorphism Autoimmune thyroid disease (AITD) Graves' disease Hashimoto's thyroiditis |
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