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| 缺碘性甲状腺肿动物模型的建立及评价 | |
| 引用本文： | 崇巍,陈威,滕卫平,单忠艳,金迎,张晓平,席联敏,张诺,满娜,佟雅洁,于扬,范晨玲,关海霞,李玉姝. 缺碘性甲状腺肿动物模型的建立及评价[J]. 中国医科大学学报, 2005, 34(2): 111-113 |
| 作者姓名： | 崇巍 陈威 滕卫平 单忠艳 金迎 张晓平 席联敏 张诺 满娜 佟雅洁 于扬 范晨玲 关海霞 李玉姝 |
| 作者单位： | 1. 中国医科大学附属第一医院急诊科,辽宁,沈阳,110001 2. 中国医科大学附属第一医院内分泌科 3. 中国医科大学内分泌研究所 4. 河北省承德市卫生局 5. 沈阳农业大学生化检测中心 |
| 摘 要： | 目的:建立可靠的缺碘性甲状腺肿动物模型.方法:给予4周龄Wistar大鼠低碘饲料和去离子水喂养3个月,全面观察甲状腺各项相关指标的变化.结果:尿碘中位数、甲状腺组织碘和激素含量及血清总甲状腺素水平显著降低,甲状腺相对重量、吸碘率、蛋白水解酶活性和血清甲状腺刺激激素水平显著增加.甲状腺在光镜下呈增生性甲状腺肿的表现.结论:成功建立了缺碘性甲状腺肿动物模型. |
| 关 键 词： | 低碘饲料 Wistar大鼠 缺碘动物模型 |
| 文章编号： | 0258-4646(2005)02-0111-03 |
| 修稿时间： | 2004-11-04 |
Establish and evaluation of iodine-deficient animal model |
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| CHONG Wei,CHEN Wei,TENG Wei-ping,SHAN Zhong-yan,JIN Ying,ZHANG Xiao-ping,XI Lian-min,ZHANG Nuo,MAN Na,TONG Ya-jie,YU Yang,FAN Cheng-ling,GUAN Hai-xia,LI Yu-shu. Establish and evaluation of iodine-deficient animal model[J]. Journal of China Medical University, 2005, 34(2): 111-113 | |
| Authors: | CHONG Wei CHEN Wei TENG Wei-ping SHAN Zhong-yan JIN Ying ZHANG Xiao-ping XI Lian-min ZHANG Nuo MAN Na TONG Ya-jie YU Yang FAN Cheng-ling GUAN Hai-xia LI Yu-shu |
| Abstract: | Objective: To establish a reliable iodine-deficient animal model. Methods:We fed 4 week-old Wistar rats with iodine-deficient forage and deionized water for 3 months and studied the relative indexes of thyroid.Results:Median of urine iodine, contents of iodine,thyroid hormone in thyroid,and level of serum total thyroxine significantly decreased. Relative weight of thyroid, thyroid iodine uptake rate, and activity of thyroid proteolytic enzyme,and level of serum thyroid-stimulating hormone significantly increased. In addition, hyperplastic goiter was observed with light microscope. Conclusion:The reliable iodine-deficient animal model has been established. |
| Keywords: | iodine-deficient forage iodine-deficient animal model Wistar rat |
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