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Preclinical testing of Peruvian anti-bothropic anti-venom against Bothrops andianus snake venom |
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| Authors: | Francisco S. SchneiderMaria C. Starling,Clara G. DuarteRicardo Machado de Avila,Evanguedes KalapothakisWalter Silva Suarez,Benigno TintayaKarin Flores Garrido,Silvia Seraylan OrmacheaArmando Yarleque,Cé sar BonillaCarlos Chá vez-Oló rtegui |
| Affiliation: | a Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antonio Carlos 6627, CP: 486, CEP: 31270-901, Belo Horizonte, Minas Gerais, Brazil b Instituto Nacional de Salud, Lima, Peru c Universidad Nacional Mayor de San Marcos, Lima, Peru |
| Abstract: | Bothrops andianus is a venomous snake found in the area of Machu Picchu (Peru). Its venom is not included in the antigenic pool used for production of the Peruvian anti-bothropic anti-venom. B. andianus venom can elicit many biological effects such as hemorrhage, hemolysis, proteolytic activity and lethality. The Peruvian anti-bothropic anti-venom displays consistent cross-reactivity with B. andianus venom, by ELISA and Western Blotting and is also effective in neutralizing the venom's toxic activities. |
| Keywords: | Bothrops andianus Andean snake Venom Anti-venom Toxicity |
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