Rugulotrosins A and B: Two new antibacterial metabolites from an Australian isolate of a Penicillium sp |
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Authors: | Stewart Michael Capon Robert J White Jonathan M Lacey Ernest Tennant Shaun Gill Jennifer H Shaddock Martin P |
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Affiliation: | Centre for Molecular Biodiversity, Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland 4072, Australia. |
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Abstract: | Two new antibacterial agents, rugulotrosin A (1) and B (2), were obtained from cultures of a Penicillium sp. isolated from soil samples acquired near Sussex Inlet, New South Wales, Australia. Rugulotrosin A (1) is a chiral symmetric dimer, and its relative stereostructure was determined by spectroscopic and X-ray crystallographic analysis. Rugulotrosin B (2) is a chiral asymmetric dimer isomeric with 1. Its structure was determined by spectroscopic analysis with comparison to the co-metabolite 1 and previously reported fungal metabolites. Both rugulotrosins A and B displayed significant antibacterial activity against Bacillus subtilis, while rugulotrosin A was also strongly active against Enterococcus faecalis and B. cereus. |
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