兔急性颅内高压模型中体感诱发电位与听觉诱发电位的变化

目的 :探索颅内压 (ICP)升高过程中体感诱发电位 (SEPs)与脑干听觉诱发电位 (BAEPs)的变化规律。方法 :采用幕上不同部位放置球囊引起急性ICP增高的动物模型。将新西兰兔 30只分为 3组 :A组动物球囊置入右顶部硬膜下 ;B组动物球囊置入右颞底 ,C组以上部位动物各半 ,球囊内不注水。结果 :(1)A组SEPsP1波幅在ICP升至(1.48± 0 .35 )kPa即发生显著变化 ,而B组中ICP达 (8.10± 1.2 5 )kPa才出现波幅显著压缩。A组BAEPs在ICP升至(9.40± 1.6 0 )kPa时才出现IV ,V ,VII波的PL延长 ,而B组在ICP为 (3.11± 0 .80 )kPa时即见III波PL显著延长。 (2 )随ICP增高 ,P1波幅先随之升高 ,继而转为下降。结论 :SEPs与BAEPs的变化不仅受ICP高低的影响 ,还与病变的部位有关 ;SEPsP1波幅在ICP增高过程中呈先升后降的趋势

Changes in somatosensory evoked potentials and brainstem auditory evoked potentials during acute intracranial hypertension in rabbits

Objective To study the changes in somatosensory evoked potentials (SEPs) and brainstem auditory evoked potentials (BAEPs) during intracranial hypertension. Method A rabbit model of acute intracranial hypertension was developed. Thirty New Zealand rabbits were divided into 3 group. Both Group A and B were groups with intracranial hypertension; Group C was the control group. In Group A, balloons were placed to the right parietal lobe beneath the dura mater; in Group B, to temporal at the middle fossa near the brainstem. Result (1) In Group A, when ICP rose to (1.48±0.35)kPa, P1 amplitude of SEPs was significantly changed, whereas latencies of Wave IV, V, and VII of BAEPs were prolonged when ICP rose to (9.40±1.60) kPa. In group B, P1 amplitude of SEPs was changed when ICP reached (8.10±1.25) kPa, and latency of Wave III of BAEPs was prolonged when ICP rose to (3.11±0.80) kPa. (2) P1 amplitude increased with ICP value when the balloon volume increased from V=0.0 ml,ICP=(0.43±0.10) kPa to V=0.4ml,ICP=(2.44±0.65) kPa and then decreased afterward. Conclusions (1) Changes in SEPs and BAEPs relate to not only ICP value but also the location of the balloon. (2) With the increasing of ICP, P1 amplitude increases firstly and then decreases.