DIFFERENTIAL BLOOD PRESSURE AND METABOLIC EFFECTS OF 9α-FLUOROCORTISOL IN MAN |
| |
| Authors: | Judith A. Whitworth Dianne Saines Robin Thatcher |
| |
| Affiliation: | Department of Nephrology, Royal Melbourne Hospital, and Howard Florey Institute of Experimental Physiology and Medicine, Melbourne, Australia |
| |
| Abstract: | The blood pressure and metabolic effects of 9 alpha-fluorocortisol at 0.15 mg/day and 1.5 mg/day were examined in man. At high dose, systolic pressure and body weight rose, and plasma [K+], urinary sodium excretion and renin concentration fell. At low dose similar metabolic effects were seen but blood pressure was unchanged. 9 alpha-Fluorocortisol has 'mineralocorticoid' effects in man at a dose which does not alter blood pressure. These studies do not provide evidence of a 'hypertensinogenic' class of steroid hormone action in man. |
| |
| Keywords: | blood pressure electrolytes glucocorticoid mineralocorticoid 9α-fluorocortisol renin sodium steroids |
| 本文献已被 PubMed 等数据库收录！ |
|
