联合放化疗对乳腺癌患者心脏毒性的临床观察

 目的 观察联合放化疗与单一化疗对乳腺癌患者心肌的损伤。方法 接受含表柔比星化疗或联合放疗的术后乳腺癌患者共68例，对其治疗前后的心电图检查结果进行统计学分析。结果 表柔比星化疗配合放射治疗的乳腺癌患者的心脏毒性明显高于单一化疗组。放化疗组出现心电图异常的发生率为36.8 %（14例），单一化疗组出现心电图异常的发生率为10 %（3例），两组比较，差异有统计学意义（P＜0.05）。结论 联合放化疗增加乳腺癌患者的心脏毒性，建议乳腺癌患者在治疗期间定期复查心电图，尤其对年龄＞60岁和有高血压、心脏疾病病史的患者尤其重要。

Clinical observation of cardiotoxicity induced by radiotherapy and chemotherapy in patients with breast cancer

Objective To observe the cardiotoxieity during combined radiotherapy and chemotherapy or chemotherapy alone in patients with breast cancer. Methods Sixty-eight patients received epirubicin or combined with radiotherapy postoperative were observed. Electrocardiogram was examined before and after each cycle of chemotherapy. The results were tested statistical comparison. Results The cardiotoxieity in breast cancer patients who were treated with both radiotherapy and chemotherapy are obviously higher than that with chemotherapy alone. The incidence of abnormal electrocardiogram in combination group was 36.8 % and 10 % in non-combination group, and with no statistical difference between the two groups. Conclusion The cardiotoxieity increased more in breast cancer patients who were treated with both radiotherapy and chemotherapy. Our results suggested that breast cancer patients should be regularly reexamined with electrocardiogram during therapy, especially whose were above 60 years and those had the history of hypertension and heart diseases.