妊娠合并梅毒患者的治疗与围产儿预后的关系

目的 了解妊娠合并梅毒患者的抗梅毒治疗对改善围产儿预后的效果。方法 对海南省人民医院及海口市妇幼保健院1995年1月至2001年1月间，妊娠合并梅毒患者进行回顾性临床分析。根据是否抗梅毒治疗。将妊娠合并梅毒患者分为治疗组与非治疗组，治疗组患者行青霉素治疗，非治疗组患者未进行抗梅毒治疗。结果 6年间两家医院分娩总人数为18701例，接受梅毒筛查者9805例，妊娠合并梅毒患者61例，发生率为6．2‰，治疗组与非治疗组围产儿死亡率分别为11．1％及83．3％，先天梅毒分别为17．6％及72．1％。结论 妊娠期梅毒是危害围产儿的严重合并症；孕期梅毒筛查是诊断的必要手段。孕期有效的青霉素治疗，将降低围产儿死亡率及先天梅毒的发生。

Treatment of syphilis in pregnancy and its perinatal prognosis

OBJECTIVE: To investigate the effects of treatment of syphilis in pregnancy on perinatal prognosis. METHODS: Patients of syphilis in pregnancy from Hainan Provincial People's Hospital and Haikou Municipal Maternal and Child Health Center during 1995.1 to 2001.1 were collected for retrospective analysis. Pregnant women with syphilis were divided into treated group and untreated group according to whether they received penicillin anti-syphilis treatment or not during pregnancy. RESULTS: The total number of deliveries in the 2 hospitals during that period was 18,701, and 61 out of 9,805 women screened for syphilis were positive, giving an incidence of 6.2/1000. The perinatal mortality rates were 11.2% in treated group and 83.3% in untreated group, and incidences of congenital syphilis were 17.6% and 72.7% respectively. CONCLUSION: Syphilis in pregnancy is a serious complication to harm the fetus. Screening of syphilis during pregnancy is necessary, and penicillin treatment is effective which may reduce the perinatal mortality rate and the birth of congenital syphilis baby.