| 四逆汤对缺血心肌谷胱甘肽S转移酶基因表达的影响 |
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| 引用本文： | 谭红梅,吴伟康,罗汉川,赵明奇,梁天文. 四逆汤对缺血心肌谷胱甘肽S转移酶基因表达的影响[J]. 中国病理生理杂志, 2002, 18(4): 413-414 |
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| 作者姓名： | 谭红梅 吴伟康 罗汉川 赵明奇 梁天文 |
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| 作者单位： | 中山大学中山医学院病理生理教研室, 广东广州 510089 |
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| 摘 要： | 目的:探讨四逆汤对缺血心肌谷胱甘肽S转移酶(GST)基因表达的影响。方法:昆明种小鼠,随机分为对照组、缺血组、缺血加四逆汤组。提取各组心肌组织总RNA通过RT-PCR,以β-actin为内参照对GST基因的表达水平进行检测。结果:缺血加四逆汤组GST基因表达显著强于对照组及缺血组。结论:四逆汤能诱导GST基因的表达,GST能催化谷胱甘肽与亲电子物质发生结合反应。
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| 关 键 词： | 四逆汤 谷胱甘肽转移酶类 基因表达 |
| 文章编号： | 1000-4718(2002)04-0413-02 |
| 收稿时间： | 2002-02-21 |
| 修稿时间： | 2002-02-21 |
Effect of Sini decoction on GST expression in the ischemic myocardium |
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| TAN Hong-mei,WU Wei-kang,LUO Han-chuan,ZHAO Ming-qi,LIANG Tian-wen. Effect of Sini decoction on GST expression in the ischemic myocardium[J]. Chinese Journal of Pathophysiology, 2002, 18(4): 413-414 |
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| Authors: | TAN Hong-mei WU Wei-kang LUO Han-chuan ZHAO Ming-qi LIANG Tian-wen |
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| Affiliation: | Department of Pathophysiology, Sun Yat-sen University of Medical Sciences, Guangzhou 510089, China |
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| Abstract: | AIM: To detect the effect of Sini decoction on glutathione S-transferase (GST) mRNA expression in the ischemic myocardium. METHODS: Kunming mice were randomly divided into control group, ischemic group and Sini decoction group. Total RNA was extracted from the myocardium of mice in each group. The effect of Sini decoction on the expression of GST gene was detected by RT-PCR. RESULTS: The expression of GST mRNA in Sini decoction group was significantly up-regulated compared with the ischemic group and control group. CONCLUSION: Sini decoction can promote the expression of GST gene, which may be related to its protective effect on ischemic myocardium. |
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| Keywords: | Sini decoction Glutathione transferases Gene expression |
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