Aryl hydrocarbon hydroxylase induction levels in patients with malignant tumors associated with smoking |
| |
| Authors: | Rolf Korsgaard Erik Trell Bo G. Simonsson Göran Stiksa Lars Janzon Bertil Hood Jörgen Oldbring |
| |
| Affiliation: | (1) Research Department I and Department of Lung Medicine, University Hospital, S-22185 Lund, Sweden;(2) Department of Tumor Cytogenetics, The Wallenberg Laboratory, University of Lund, S-22007 Lund, Sweden;(3) Section of Preventive Medicine, Departments of Internal Medicine and Community Healt Sciences, University of Lund, Malmö General Hospital, S-21401 Malmö, Sweden;(4) Department of Internal Medicine, University of Lund, Malmö General Hospital, S-21401 Malmö, Sweden;(5) Department of Urology, University of Lund, Malmö General Hospital, S-21401 Malmö, Sweden |
| |
| Abstract: | Summary The levels of aryl hydrocarbon hydroxylase (AHH) inducibility were assessed in 173 patients with cancers statistically associated with smoking, i.e., squamous cell and transitional cell carcinomas, at various sites. In 34 patients with carcinomas of the oral cavity, 41 patients with laryngeal carcinomas, and 22 patients with pulmonary carcinomas there was a highly significant overrepresentation of high inducers, whereas 30 patients with carcinomas of the renal pelvis and ureter and 46 patients with urinary bladder carcinomas did not differ significantly in this respect from a control population comprising 92 subject with no history of neoplastic disease.The results add further support to the concept of AHH as a major activator of carcinogens belonging to the group of polycyclic aromatic hydrocarbons (PAH) when these affect·the oral cavity and/or the respiratory tract.The role of AHH in urothelial carcinogenesis seems to be less explicit. |
| |
| Keywords: | Aryl hydrocarbon hydroxylase Cancer Carcinogenesis Smoking |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
