Detection of linkage between a quantitative trait and a marker locus by the lod score method: sample size and sampling considerations |
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| Authors: | F. DEMENAIS ,G. M. LATHROP&dagger ,J. M. LALOUEL&dagger |
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| Affiliation: | *Unitéde Recherches de Génétique Épidémiologique, I.N.S.E.R.M. U.155, Château de Longchamp, Bois de Boulogne, 75016 Paris, France;†Howard Hughes Medical Institute, University of Utah Medical School, Salt Lake City, UT 84132, U.S.A. |
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| Abstract: | A simulation study is here conducted to measure the power of the lod score method to detect linkage between a quantitative trait and a marker locus in various situations. The number of families necessary to detect such linkage with 80% power is assessed for different sets of parameters at the trait locus and different values of the recombination fraction. The effects of varying the mode of sampling families and the sibship size are also evaluated. |
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