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Human pharmacokinetics of analgesics and methods for their determination in biological fluids |
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| Authors: | Miskolczi P Vereczkey L |
| Affiliation: | Department of Pharmacokinetics and Drug Metabolism, Chemical Works of Gedeon Richter Ltd, P.O. Box 27, H-1475 Budapest 10, Hungary. |
| Abstract: | The main pharmacokinetic data of analgesics--biological half-lives, apparent volumes of distribution, total body clearances--obtained in humans, and their clinical relevance are summarized. Special emphasis has been given to the analytical methods used for the quantitative determination of these drugs in biological fluids. |
| Keywords: | Morphine codeine pethidine methdone pentazocine buprenorphine ketamine salicylic acid derivatives bioavailability plasma clearance pharmacokinetics drug half-lives volume of distribution. |
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