原发性高血压患者动态血压和颈动脉斑块与认知功能相关性研究

目的探讨原发性高血压患者动态血压、颈动脉斑块对认知功能的影响。方法将594例高血压患者按24h血压节律及颈动脉斑块的有无分为4组,(1)杓型血压+无颈动脉斑块组(149例);(2)杓型血压+颈动脉斑块组(144例);(3)非杓型血压+无颈动脉斑块组(154例);(4)非杓型血压+颈动脉斑块组(147例)。所有患者进行24h动态血压检测。彩色电脑声像仪逐节段观察颈动脉管壁内膜情况及有无斑块形成。使用简易智能状态检查量表(MMSE)对所有患者进行认知功能调查。结果非杓型血压+颈动脉斑块组、杓型血压+颈动脉斑块组、非杓型血压+无颈动脉斑块组、杓型血压+无颈动脉斑块组MMSE分别为(26.2±1.2)分、(28.3±1.5)分、(28.2±1.5)分(、28.8±0.6)分,非杓型血压+颈动脉斑块组MMSE与其他3组比较,差异有统计学意义(P<0.05,P<0.01)。logMMSE与24 h平均收缩压、昼间平均收缩压、昼间平均脉压、夜间平均收缩压、夜间平均舒张压、夜间平均脉压及颈动脉斑块呈负相关,与收缩压夜间下降率及舒张压夜间下降率呈正相关。结论动态血压节律变化及颈动脉斑块的形成与原发性高血压患者的认知功能损害相关。

Correlation between ambulatory blood pressure,carotid plaque and cognitive function in essential hypertensive patient

Objective To explore the effect of ambulatory blood pressure and carotid plaque on cognitive function in essential hypertensive patient.Methods 594 hypertensive patients were divided into four groups according to blood pressure level and carotid plaque,namely,dipper and no carotid plaque group,dipper and carotid plaque group,non-dipper and no carotid plaque group and non-dipper and carotid plaque group.All the patients underwent 24-hour ambulatory blood pressure monitoring.Carotid artery ultrasonic examinat...