两种不同小梁切除术治疗开角型青光眼的Meta 分析

目的：评价非穿透性小梁手术和小梁切除对降低开角型青光眼患者眼压的疗效。

方法：计算机检索Cocharane图书馆、PubMed(1966～2013)、Embase(1980～2013)、中国生物医学文献数据库(1979～2013)中关于非穿透性小梁手术和小梁切除术对降低开角型青光眼患者眼压的疗效的随机对照试验、同时筛检纳入文献的参考文献。对文献质量进行评价，对符合质量标准的随机对照试验(Randomized Controlled Trial，RCT)用RevMan4.2软件进行Meta分析。

结果：共纳入10个RCT，7篇研究均显示，非穿透性小梁切除术与小梁切除术比较，小梁切除术能提高患者术后眼压降低的水平和手术的成功率，但是8篇研究均显示非穿透性小梁切除术较传统小梁切除术能更有效的降低术后并发症发生率。

结论：与非穿透性小梁切除术相比，传统小梁切除术能够提高眼压的降低水平和手术成功率； 而非穿透性小梁切除术能较好降低术后并发症的发生率。

Non-penetrating trabecular surgery versus trabeculectomy for the treatment of open angle glaucoma-Meta analysis

AIM: To assess the efficacy of non-penetrating trabecular surgery versus trabeculectomy for lowering the intraocular pressures(IOP)of patients with open angle glaucoma.

METHODS: We searched the Cochrane Library, PubMed(1966 to 2013), Embase(1980 to 2013)and CBMdisc(1979 to 2013)for the randomized clinical trials of non-penetrating trabecular surgery and trabeculectomy. We also screened relevant journals and references to evaluate the quality of the literatures. The Cochrane Collaboration's RevMan 4.2 software was used for Meta analysis.

RESULTS: Ten RCTs with previously untreated open angle glaucoma were included. Seven results showed that compared with non-penetrating trabecular surgery, trabeculectomy can better improve the level of postoperative IOP reduction and the success rate of surgery. But eight results showed that compared with trabeculectomy, non-penetrating trabecular surgery can reduce the incidence of postoperative complications.

CONCLUSION: Compared with non-penetrating trabecular surgery, trabeculectomy can better improve the level of postoperative IOP reduction and the success rate of surgery. But non-penetrating trabecular surgery can reduce the incidence of postoperative complications of surgery.