Electroretinographic evaluation in adult diabetics |
| |
Authors: | Sang-Ha Kim Sang-Hee Lee Jae-Yong Bae Jin-Ho Cho Yune-Sik Kang |
| |
Institution: | (1) Department of Biomedical Engineering, Kyungpook National University Hospital, Taegu, Korea;(2) Department of Preventive Medicine, Kyungpook National University Medical School, Taegu, Korea;(3) Department of Ophthalmology, Kyungpook National University Hospital, 52, 2-Ga Samduk-Dong Jung-Gu, 700-412 Taegu, Korea |
| |
Abstract: | In cross-sectional fashion, we recorded the maximal combined response and 30-Hz flicker responses in 178 adult diabetics and
40 normal controls according to the recommendations of the International Society of Clinical Electrophysiology of Vision.
The oscillatory potentials were extracted from the maximal combined response by high-pass filtering. The clear media and attached
retina were criteria for inclusion in this study. The data were statistically analyzed with the expectation that this procedure
may provide a new feature that could have some clinical significance. Timing delays occurred more frequently than amplitude
reductions in the maximal combined response and flicker responses, while amplitude reductions were more common in the first
and second oscillatory potentials. The hypernormal b-wave amplitude was rare. The summed amplitude of the oscillatory potentials
was highly correlated with the total power of the oscillatory potentials (the frequency domain). A reduction of the second
oscillatory potential amplitude was more common than a reduction of the summed amplitude or total power. The electroretinographic
component that demonstrates retinal dysfunction in the earlier stage may be a valuable indicator. In the early stage, a delay
in the a-wave time and a reduction in the second oscillatory potential amplitude were the most frequent abnormalities: analysis
of variance demonstrated that the summed amplitude of the oscillatory potentials and second oscillatory potential amplitude
and time were the most sensitive measures of the diabetic retina. Hence, the second oscillatory potential amplitude may be
the most sensitive and valuable indicator representing a quantitative measure of overall retinal dysfunction. |
| |
Keywords: | diabetes electroretinogram Fourier transform oscillatory potential |
本文献已被 SpringerLink 等数据库收录! |
|