| 抗人肺癌细胞转移相关抗原单克隆抗体的制备及初步鉴定 |
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| 引用本文： | 于爱新,陈璋,宝勒日,韩立群,王吾如.抗人肺癌细胞转移相关抗原单克隆抗体的制备及初步鉴定[J].细胞与分子免疫学杂志,1992(2). |
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| 作者姓名： | 于爱新 陈璋 宝勒日 韩立群 王吾如 |
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| 作者单位： | 中国医学科学院血液学研究所，中国医学科学院血液学研究所，哈尔滨医科大学，哈尔滨医科大学，哈尔滨医科大学 天津 300020，天津 300020，哈尔滨 150086，哈尔滨 150086，哈尔滨 150086 |
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| 摘 要： | 用转移能力及其它生物学特性不同的2个人肺腺癌细胞系免疫BALB/c小鼠,制备出一组可与人肺腺癌细胞发生特异性反应,而与其它脏器肿瘤组织无交叉反应的单克隆抗体。经初步鉴定,其中的3个单抗分别识别低转移或高转移肺腺癌细胞系表面抗原。
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| 关 键 词： | 肺癌 肿瘤转移 抗体 单克隆 |
Production and characterization of monoclonal antibodies against human lung cancer antigen associated with metastasis |
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| Yu Aixin,Chen Zhan et al.Production and characterization of monoclonal antibodies against human lung cancer antigen associated with metastasis[J].Journal of Cellular and Molecular Immunology,1992(2). |
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| Authors: | Yu Aixin Chen Zhan |
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| Abstract: | A group of monoclonal antibodies ( McAbs ) against human lung adenocar-cinoma cells were obtained by using high-metastatic human lung adenocarcinoma cell line Anip 973 and its low-metastatic parent line AGZY-83-a for immunization of BALB/c mice. Preliminary characterization showed that, among these McAbs, HILh-4 reacted specifically with Anip 973 whereas both HIL1-5 and HIL1-10 reacted with AGZY-83-a and LTEP-a-1. Cross absorption assay demonstrated the distinction of surface antigens between high- and low metastatic tumour cell lines. The relationship between these molecules and the cells' metastatic potency needs further study in future. |
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| Keywords: | lung cancer tumour metastasis antibody monoclonal |
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