| 乙酰肝素酶反义寡核苷酸对裸鼠食管癌uPA蛋白表达影响 |
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| 引用本文： | 陈奎生,张建文,张岚,高冬玲,张云汉,郭克民,温洪涛.乙酰肝素酶反义寡核苷酸对裸鼠食管癌uPA蛋白表达影响[J].医药论坛杂志,2004,25(22):8-9. |
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| 作者姓名： | 陈奎生 张建文 张岚 高冬玲 张云汉 郭克民 温洪涛 |
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| 作者单位： | 郑州大学第一附属医院,郑州市,450052;郑州大学医学院法医学教研室,郑州市,450052 |
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| 基金项目： | 河南省自然科学基金资助项目 (0 3 1164 3 70 0 )，河南省高校青年骨干教师资助项目 [豫教育 (2 0 0 3 ) 10 0号 ]，教育部“十五”、“2 11工程”重点学科建设项目 [教重办 (2 0 0 2 )第 2号 ] |
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| 摘 要： | 目的 探讨乙酰肝素酶反义寡核苷酸对裸鼠食管癌移植瘤组织中uPA蛋白表达的影响。方法 采用免疫组化SP法对裸鼠食管癌移植瘤组织中uPA蛋白的表达进行了检测。结果 4条乙酰肝素酶反义寡核苷酸 (2 0mol/L)对裸鼠体内食管癌移植瘤中uPA蛋白表达表现出不同程度的抑制作用 ,实验组中uPA蛋白表达与N -ODN转染组、未经转染的空白对照组相比 ,差异均有统计学意义 (P <0 .0 5 )。结论 乙酰肝素酶反义寡核苷酸通过对裸鼠食管癌移植瘤组织中uPA蛋白表达 ,从而抑制肿瘤的浸润转移。
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| 关 键 词： | 乙酰肝素酶 反义寡核苷酸 食管癌 裸鼠 uPA蛋白表达 |
| 文章编号： | 1672-3422(2004)22-0008-02 |
| 修稿时间： | 2004年7月18日 |
Effects of Heparanase Antisense Oligodeoxynucleotides for uPA Protein Expression in Tumor Carried by Nude Mice |
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| CHEN Kuisheng,ZHANG Jianwen,ZHANG Lan,et al.Effects of Heparanase Antisense Oligodeoxynucleotides for uPA Protein Expression in Tumor Carried by Nude Mice[J].Journal of Medical Forum,2004,25(22):8-9. |
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| Authors: | CHEN Kuisheng ZHANG Jianwen ZHANG Lan |
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| Institution: | CHEN Kuisheng,ZHANG Jianwen,ZHANG Lan,et alDepartment of Pathology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China |
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| Abstract: | Objective To investigate the effects of heparanase antisense oligodeoxynucleotide on the expression of uPA in tumor carried by nude mice. Methods The expression of uPA in tumor carried by nude mice was detected by immunohistochemistry. Results The expression of uPA protein in transplanted tumor was inhibited by 4 heparanase antisense oligodeoxynucleotides (20mol/L), there was significant difference found between N-ODN transfected group , non-transfected group and experimental group(P<0.05). Conclusion Heparanase antisense oligodeoxynucleotides was an effective inhibitor and it provided a new clue for preventing invasion and metastasis of tumors clinically. |
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| Keywords: | Heparanase Antisense oligodeoxynucleotide Esophageal cancer Nude mice uPA expression |
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