| 选择性COX-2抑制剂的用药风险与新功用 |
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| 引用本文： | 潘献柱,汪思应,王林,程洁. 选择性COX-2抑制剂的用药风险与新功用[J]. 药学进展, 2006, 30(4): 165-170 |
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| 作者姓名： | 潘献柱 汪思应 王林 程洁 |
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| 作者单位： | 1. 安徽医科大学病理生理学教研室,安徽,合肥,230032
2. 军事医学科学院放射与辐射医学研究所,北京,100850 |
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| 摘 要： | 综述近年来国内外有关选择性COX-2抑制剂的潜在用药风险及新功用的报道，为探讨该类药物的发展方向提供参考。选择性COX-2抑制剂是一类新型非甾体抗炎药，由于其胃肠毒性低而倍受关注，但潜在的心血管风险限制了其临床上的应用，此类药物的去留引起了极大争议。
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| 关 键 词： | 非甾体抗炎药 选择性COX-2抑制剂 风险 功用 |
| 文章编号： | 1001-5094（2006）04-0165-06 |
| 收稿时间： | 2005-11-16 |
| 修稿时间： | 2005-11-16 |
Potential Risks and Novel Effects of Selective COX-2 Inhibitors |
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| PAN Xian-zhu,WANG Si-ying,WANG Lin,CHENG Jie. Potential Risks and Novel Effects of Selective COX-2 Inhibitors[J]. Progress in Pharmaceutical Sciences, 2006, 30(4): 165-170 |
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| Authors: | PAN Xian-zhu WANG Si-ying WANG Lin CHENG Jie |
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| Affiliation: | 1. Department ofPathophysiology, Anhui Medical University, Hefei 230032, China ; 2. Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China |
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| Abstract: | The potential risks and novel effects of selective COX-2 inhibitors reported in recent years were reviewed to discuss the development of this kind of drugs. The clinical application of selective COX-2 inhibitors, a class of new NSAIDs with low gastrointestinal toxicity, is limited in view of their potential cardiovascular events, which have aroused grave concern. |
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| Keywords: | NSAID Selective COX-2 inhibitor Risk Effect |
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