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| clusterin、bcl-2在非小细胞肺癌中的表达及其相关性 | |
| 引用本文： | 李奎英,吴立平,刘婷,夏洪梅.clusterin、bcl-2在非小细胞肺癌中的表达及其相关性[J].现代医药卫生,2011,27(3):328-329. |
| 作者姓名： | 李奎英 吴立平 刘婷 夏洪梅 |
| 作者单位： | 1. 潍坊医学院,山东,潍坊,261042 2. 潍坊市人民医院呼吸内科,山东,潍坊,261042 3. 淄博市第一医院呼吸内科,山东,淄博,255200 |
| 摘 要： | 目的:研究clusterin、bcl-2在非小细胞肺癌(NSCLC)组织中的表达及其相关性,探讨其与非小细胞肺癌发生、发展的关系.方法:免疫组化pv9000通用型二步法检测53例NSCLC组织、20例癌旁组织中簇集蛋白(Clusterin)、bcl-2的阳性表达情况.结果:非小细胞肺癌组clusterin、bcl-2阳性表达率高于癌旁组织(P＜0.05);clusterin、bcl-2表达与肺癌TNM分期、分化程度及淋巴结转移均有关(P＜0.05),但与组织学类型、性别、年龄无关(P＞0.05);在非小细胞肺癌组织中,clusterin、bcl-2表达成正相关(r=0.396,P＜0.05).结论:clusterin和bcl-2的高表达可能与非小细胞肺癌的发生、发展和浸润有关,二者在肺癌的发生发展中可能存在协同作用. |
| 关 键 词： | 非小细胞肺癌 clusterin bcl-2 细胞凋亡 免疫组化 |
Clusterin and bcl-2 expressions and their correlations in non-small cell lung cancer |
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| LI Kui-ying , WU Li-ping , LIU Ting , XIA Hong-mei.Clusterin and bcl-2 expressions and their correlations in non-small cell lung cancer[J].Modern Medicine Health,2011,27(3):328-329. | |
| Authors: | LI Kui-ying WU Li-ping LIU Ting XIA Hong-mei |
| Institution: | LI Kui-ying1,WU Li-ping2,LIU Ting3,XIA Hong-mei3(1.Weifang Medical College,Weifang,Shandong 261042,China,2.Department of Respiration,Weifang People's Hospital,3.Department of Respiration,Zibo First Hospital,Zibo,Shangdong 255200,China) |
| Abstract: | Objective:To study the expressions of clusterin and bcl-2 and their correlations with non-small cell lung cancer(NSCLC),and to discuss their significance in the occurrence and development of lung cancer.Methods:To examine the expressions of clusterin and bcl-2 in 55 samples of non-small cell lung cancer tissues and 20 samples of adjacent normal lung tissues by pv9000 immunohistochemistry.Results:The positive rates of clusterin and bcl-2 in NSCLC were significantly higher than those of adjacent normal lung t... |
| Keywords: | Non-small cell lung cancer Clusterin bcl-2 Apoptosis Immunohistochemistry |
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