| 利用Siemens Explora FDG4化学合成模块合成18F-FDG的方法及质量控制 |
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| 引用本文： | 王清,汝琦,丁伟,高山,崔新建.利用Siemens Explora FDG4化学合成模块合成18F-FDG的方法及质量控制[J].现代医药卫生,2011,27(5):656-657. |
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| 作者姓名： | 王清 汝琦 丁伟 高山 崔新建 |
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| 作者单位： | 青岛市中心医院PET/CT中心,山东,青岛,266000 |
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| 摘 要： | 目的:建立18F-FDG注射剂的合成工艺及质量控制方法.方法:采用西门子公司的Explora FDG4化学合成模块合成可供注射用的18F-FDG.结果:制得18F-FDG注射剂,TLC测定放射化学纯度大于98%,合成效率达58%以上.结论:采用本方法合成18F-FDG注射剂可在满足日常检查需要的同时最大限度的减少工作人员受到的辐射.
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| 关 键 词： | 18F-氟代脱氧葡萄糖 化学合成 质量控制 PET/CT |
New method for preparation and quality control of ~(18)F-FDG synthesized by Siemens Explora FDG4 synthetic system |
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| WANG Qing,RU Qi,DING Wei,et al..New method for preparation and quality control of ~(18)F-FDG synthesized by Siemens Explora FDG4 synthetic system[J].Modern Medicine Health,2011,27(5):656-657. |
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| Authors: | WANG Qing RU Qi DING Wei |
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| Institution: | WANG Qing,RU Qi,DING Wei,et al.(PET/CT Center,Qingdao Central Hospital,Qingdao,Shandong 266042,China) |
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| Abstract: | Objective:To develop a new method for the preparation and the quality control of 18F-FDG injection.Methods:The acid hydrolysis method was adopted to synthesize 18F-FDG injection by Siemens Explora FDG4 synthesis system.Results:The prepared 18F-FDG injection synthesized by the new method had good qualities.The combined efficiency was above 58% and the radiochemistry purity was above 98% detected by TLC.Conclusion:The 18F-FDG injection prepared in this method is suitable for clinical application and will redu... |
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| Keywords: | 18F-FDG Chemical synthesis Quality control PET/CT |
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