| Affiliation: | (1) Department of Biology, UNESP, S?o Paulo State University, IBILCE, Institute of Bioscience, Language & Literature and Exact Science, Rua Crist?v?o Colombo, 2265, Bairro Jardim Nazareth, CEP 15054-010 S?o Jos? do Rio Preto, S?o Paulo, Brazil;(2) USP, S?o Paulo University, Rua do Mat?o, trav 14, n? 321, Cidade Universit?ria, CEP 05508-900 S?o Paulo, S?o Paulo, Brazil;(3) Faculty of Medicine, Department of Gastroenterology, Laboratory of Hepatology and Gastroenterology from Institute of Tropical Medicine, USP, S?o Paulo University, Av Dr Arnaldo, 455, Cerqueira C?sar, CEP: 01246903 S?o Paulo, SP, Brazil;(4) Department of Clinical Pathology, Albert Einstein Israeli Hospital, Av Albert Einstein, 627/701, CEP 05652-000 S?o Paulo, SP, Brazil;(5) Viral Immunology Laboratory, Butantan Institute, Av Vital Brasil n? 1500, CEP 05503-900 Butant?, S?o Paulo, SP, Brazil |
| Abstract: | Background The quasispecies nature of HCV may have important implications for viral persistence, pathogenicity and resistance to antiviral agents. The variability of one of the viral proteins, NS5A, is believed to be related to the response to IFN therapy, the standard treatment for infection. In this study we analyzed the quasispecies composition of NS5A protein in patients infected with HCV genotype 3a, before IFN therapy. |
