连续动态观察乳酸脱氢酶对MDS预后判定的意义

本研究旨在动态观察MDS患者的乳酰脱氢酶(LDH)的表达水平,初步探讨LDH对MDS患者预后判定的意义。回顾分析我院2001-2009年确诊的163例MDS患者,诊断时的LDH的表达水平,随访患者的LDH的变化情况及其与MDS的预后、生存期和疾病进展的关系;监测血细胞、骨髓原始细胞比例和核型,并分析其与LDH水平的关系。结果表明:163例患者在诊断时LDH表达值为214U/L(102-865U/L),LDH升高组MDS患者的中位生存期为25.6月,LDH正常组MDS患者的中位生存期为56.8月,两组比较差异显著(p<0.05)。按照IPSS预后积分系统分类,LDH升高多在中危-2和高危组,与低危和中危-1比较差异显著(p<0.05)。有疾病进展的MDS患者的LDH值比诊断初期和进展前明显升高,而无疾病进展的MDS患者的LDH水平基本保持稳定范围,无明显升高,两组比较差异显著(p<0.05)。与其他预后指标比较,LDH是一个独立的预后指标。结论:LDH值可作为MDS患者的预后判断指标,有助于早期识别MDS进展和白血病的发生,从而选择合理的治疗方案。

Prognostic Significance of Serial Determinations of Lactate Dehydrogenase in Follow-up for Patients with Myelodysplastic Syndrome

This study was aimed to dynamically observe the expression level of lactate dehydrogenase(LDH) in MDS patients and to expolre the significance of LDH level for prognostic judgement of MDS patients.The expression level of LDH in 163 confirmedly diagnosed patients from 2001 to 2009 years in our hospital,the changes of LDH level in follw-up patients and relation of the LDH changes to prognosis,survival time and MDS progression,as well as the relation of LDH level to blood cell count,ratio and karyotype of blas...