Effects of hyaluronan on periosteal grafts for large full-thickness defects in rabbit articular cartilage |
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Authors: | A Katsumi Y Harada Y Wada I Kanisawa M Ishima H Moriya |
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Affiliation: | (1) Department of Orthopaedic Surgery, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan, JP |
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Abstract: | We studied the effects of hyaluronan (HA) on chondrogenesis in periosteal grafts in rabbit knees to elucidate the effects
of this agent in the repair of articular cartilage. Large full-thickness defects of the articular cartilage were created in
the anteromedial part of the femoral articular surface of bilateral knee joints. Periosteal grafts were then harvested and
sutured onto the defects. HA was injected in the right knee immediately after the operation and then once a week for 4 weeks
(HA group). The same volume of saline was injected in the left knee in the control group. The animals were killed 2, 5, 8,
and 12 weeks after the operation. Macroscopic and histological findings of the regenerated tissue were evaluated with a semiquantitative
histological grading system. The total histological scores of the HA group were better than those in the control group at
each time examination point. At 12 weeks, in particular, the scores for surface regularity and integration to adjacent articular
cartilage were significantly better in the HA group than in the control group (P < 0.05). No significant differences were observed between the two groups in regard to the area healed (%). HA may have beneficial
effects on the repair of large full-thickness defects of the articular cartilage with autologous periosteal grafts.
Received for publication on Feb. 18, 1998; accepted on Oct. 20, 1998 |
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Keywords: | : hyaluronan periosteal graft cartilage repair mesenchymal stem cell cell differentiation |
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