SA、F/TPSA及PSAD在前列腺癌诊断中的作用

目的 :探讨血清前列腺特异抗原 (PSA) ,血清总PSA及游离PSA比值 (F/TPSA)及前列腺特异性抗原密度(PSAD)在前列腺癌诊断中的作用。方法 :对 5 1例前列腺癌患者及 14 5例良性前列腺增生症患者PSA、F/TPSA及PSAD值的差异进行分析、比较。结果 :前列腺癌组血清PSA及PSAD高于良性前列腺增生组 ;而F/TPSA值低于良性前列腺增生组 ,差异均有显著性。结论 :PSA >4ng·ml-1作为筛选前列腺癌的临界值存在一定缺陷 ;当PSA <10ng·ml-1,F/T值有助于鉴别前列腺癌和良性前列腺增生 ;而PSAD对于筛选前列腺活检病例亦有一定价值。

Role of PSA,F/TPSA and PSAD in Diagnosis of Prostate Carcinoma

Objective: To study the role of serum prostate specific antigen(PSA), ratio of free-total PSA(F/TPSA) and density of PSA (PSAD) in the diagnosis of prostate carcinoma(PCa). Methods: 51 cases of PCa and 145 cases benign prostatic hyerplasia(BPH) were involved from September of 1998 to September of 2003 and the differences of PSA,F/TPSA and PSAD between these two kinds of diseases were compared. Results: serum PSA and PSAD were higher in prostate carcinoma, while F/TPSA was higher in BPH. There was statistic difference between the two groups. Conclusion: It sounds unresonable as PSA>4 ng·ml -1 is regarded as a reasonable critical value for the diagnosis of prostate carcinoma. When PSA level<10 ng·ml -1,F/T ratio is of significant value to differentiate PCa from BPH patients. And PSAD is important for selecting the cases of prostatic biopsy.