二甲双胍干预对乳腺癌化疗伴糖代谢异常患者血糖的影响

目的 研究二甲双胍干预对乳腺癌化疗伴糖代谢异常患者血糖的影响.方法 整群选择2012年2月—2014年8月来该院行乳腺癌化疗,伴糖代谢紊乱的60例患者作为研究对象,随机分为两组. 对照组给予AC-T化疗方案,同时给予患者饮食控制和运动治疗,观察组在对照组基础上加用二甲双胍,观察两组血糖控制情况. 结果 观察组化疗结束时和化疗结束后3个月正常血糖患者例数显著多于对照组,差异具有统计学意义(P<0.05). 观察组化疗结束时和化疗结束后3个月糖代谢异常患者例数显著低于对照组,差异具有统计学意义(P<0.05). 观察组化疗结束时和化疗结束后3个月,糖尿病患者例数低于对照组,但无统计学意义(P>0.05). 结论 二甲双胍对于控制乳腺癌化疗伴糖代谢紊乱患者血糖水平效果显著,且具有潜在抗肿瘤作用,值得进一步研究.

Effect of Metformin Intervention on Blood Sugar of Patients with Breast Cancer Chemotherapy with Abnormal Glucose Metabolism

Objective To research the effect of metformin intervention on blood sugar of patients with breast cancer chemotherapy with abnormal glucose metabolism. Methods 60 cases of patients with breast cancer chemotherapy with ab-normal glucose metabolism in our hospital from February 2012 to August 2014 were selected as the research object and randomly divided into two groups, the control group received AC-T chemotherapy plan, and were treated with diet control and exercise, the observation group were given additional metformin on the basis of the control group, the blood sugar con-trol conditions of the two groups were observed. Results The case number of patients with normal blood sugar at the end of chemotherapy and in 3 months after chemotherapy in the observation group was obviously more than that in the control group, and the difference was statistically significant (P<0.05), the case number of patients with abnormal glucose metabolism at the end of chemotherapy and in 3 months after chemotherapy in the observation group was obviously lower than that in the control group , the difference was statistically significant (P<0.05), the cases number of patients with dia-betic at the end of chemotherapy and in 3 months after chemotherapy in the observation group was lower than that in the control group but the difference was not statistically significant (P>0.05). Conclusion Metformin for controlling the blood sugar levels of patients with breast cancer chemotherapy with abnormal glucose metabolism has an obvious effect and has a potential anti-tumor effect, which is further research.