| 成人急性淋巴细胞白血病和杂合性急性白血病MIC分型及预后分析 |
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| 引用本文： | 党辉,傅剑峰,单福香,史惠琳,洪波,丘镜滢,王德炳,陈珊珊,吴萍娜. 成人急性淋巴细胞白血病和杂合性急性白血病MIC分型及预后分析[J]. 北京大学学报(医学版), 1995, 0(5) |
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| 作者姓名： | 党辉 傅剑峰 单福香 史惠琳 洪波 丘镜滢 王德炳 陈珊珊 吴萍娜 |
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| 作者单位： | 北京医科大学血液病研究所 |
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| 摘 要： | 对２９例成人急性淋巴细胞白血病和２例杂合性急性白血病的形态学、免疫学及细胞遗传学的研究结果发现，成人急淋白血病中日细胞表型多见，其次为Ｔ细胞表型，初诊时骨髓染色体异常发生率为６５％，数目异常较儿童异常患者少见，结构异常中５５％为Ｐｈ染色体，具有Ｐｈ染色体者完全缓解率低。杂合性急性白血病双表型、双克隆型各１例，均有复杂Ｐｈ染色体畸变。
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| 关 键 词： | 白血病，淋巴细胞性，急性／遗传学，白血病，混合细胞／遗传学，免疫表型，费城染色体 |
ANALYSIS OF MIC AND CLINICAL PROGNOSIS IN ADULT ACUTE LYMPHOBLASTIC LEUKEMIA AND HYBRID LEUKEMIA |
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| Institute of Hematology Hong Bo,Qiu Jingying,Wang Debing,et al. ANALYSIS OF MIC AND CLINICAL PROGNOSIS IN ADULT ACUTE LYMPHOBLASTIC LEUKEMIA AND HYBRID LEUKEMIA[J]. Journal of Peking University. Health sciences, 1995, 0(5) |
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| Authors: | Institute of Hematology Hong Bo Qiu Jingying Wang Debing et al |
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| Abstract: | he results of the morphological,immunological and cytogenetic analysis(MIC) in 29 patients with adult a-cute lymphoblastic leukemia(ALL )and 2 patients with hybrid acute leukemia(HAL)were reported.It was foundthat 8 of 13 parients had B cell-ALL and 6 had T cell-ALL At diagnosis,65% of structural chromosomal abnor- malities was seen in 29 patients and Ph chromosome was found in 55% patients. The incidence of chromosomal nu- merical abnormalities was relatively low in our patients compared with children ALL Two patients with HALwere diagnosed by MIC analysis and their complex chromosome abnormal Ph translocation was reported.The com-plete remission wa5 only seen in one of seven patients with Ph translocation. |
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| Keywords: | Headings Leukemia lymphocytic acute/genet Leukemia mixed-cell/genet Immunophenotype Philadelphia chromosorne |
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