T淋巴细胞发育分化与自身免疫性疾病

T淋巴细胞在胸腺这一独特微环境中发育分化成幼稚CD4T淋巴细胞、幼稚CD8T淋巴细胞、调节性T淋巴细胞等不同细胞亚群,然后在一定条件下离开胸腺到外周淋巴组织器官,接触抗原后在不同的细胞因子作用下进一步成熟分化为不同的功能性亚群。CD4T淋巴细胞分化为Th1、Th2、Th17;调节性T淋巴细胞分为天然型和诱导型;CD8T淋巴细胞分化为记忆、效应以及调节/抑制性CD8T淋巴细胞。功能不同的T淋巴细胞亚群主导着不同的自身免疫性疾病。

T Lymphocytes Differentiation and Autoimmune Diseases

T lymphocytes develope and differentiate to different subsets such as naive CD4T cells,naive CD8T cells,regulatory T cells and so on in unique micro-enviroment of thymus. Then emigrate from the thymus to peripheral lymph organs under some circumstance where the T cells contact with antigens,and further differentiate to distinct functional subsets under different cytokines. CD4T cells differentiate to Th1、Th2、 Th17; Regulatory T cells have two types: natural regulatory and induced regulatory T cells; naive CD8T cells differentiate to memory,effector,suppressor CD8T cells. These distinct functional subsets predominate differ- ent autoimmune diseases.