环孢素A峰浓度监测在异基因干细胞移植术中的意义研究

目的:探讨环孢素A(CsA)峰浓度(C2)监测在异基因干细胞移植术中的意义。方法:采用荧光偏振免疫(FPIA)法分别对9例和12例异基因干细胞移植术患者进行谷浓度(C0)和C2监测。结果:当C0组浓度在200~400μg·L-1、C2组浓度在500~700μg·L-1时,可提高CsA的效果并降低CsA的肝肾毒副作用。C2比C0更能有效预测排斥反应的发生。结论:CsA血药浓度受多种因素的影响,对异基因干细胞移植患者进行C监测比C监测更有效。

Clinical Research of Therapeutic Drug Monitoring for CsA in Allogeneic Hematopoietic Stem Cell Transplantation

OBJECTIVE： To explore the clinical role of two- hour（C2） of CsA in allogeneic hematopoietic stem cell transplantation. METHODS：The whole blood CsA concentration of 9 patients of C0 and 12 of C2 were determined by FPIA method . RESULTS： The satisfactory immunosuppressive concentration was found as follow： C0 was 200-400 μg·L^-1 and C2 was 500- 700 μg·L^-1.Both C0 and C2 could predict the acute rejection and side - effects, but C2 is more effective.CONCLUSION： The factors that affect the whole blood concentration of CsA were complex. CsA blood concentration monitoring can be used to guide rational use of CsA,but C2 is more effective than C0.