| TGF—β1表达与小鼠病毒性心肌炎细胞凋亡的关系 |
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| 引用本文： | 钱素娟,郭彩玲.TGF—β1表达与小鼠病毒性心肌炎细胞凋亡的关系[J].中国地方病防治杂志,1998,13(2):75-77. |
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| 作者姓名： | 钱素娟 郭彩玲 |
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| 作者单位： | 哈尔滨医科大学克山病研究所
(钱素娟，周令望，迟月明，修英霞，于维汉)，哈尔滨医科大学微生物教研室
(郭彩玲，谷鸿喜)，哈尔滨医科大学免疫教研室(徐鸿薇) |
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| 摘 要： | 本实验通过给ＢＡＬＢ／Ｃ小鼠腹腔接种柯萨奇Ｂ－３ｍ病毒（ＣＶＢ３ｍ）诱发病毒性心肌炎（ＶＭＣ）感染病毒９ｄ后，ＶＭＣ检出率９３．３３％，应用原位末端标记法（Ｔ／ＶＮＥＬ）及免疫组化技术检测发现，７６．６７％感染病毒鼠心肌中发现凋亡细胞，７３．３３％，有ＴＧＦ－β１的表达，二者之间分布区域一致，提示细胞凋亡可能参与ＣＶＢ３ｍ诱导的ＶＭＣ的发生，发展，而ＴＧＦ－β１可能参与ＶＭＣ细胞凋亡的调控。
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| 关 键 词： | 病毒性心肌炎 细胞凋亡 TGF－β1 |
THE RELATION OF EXPRESSION OF TGF-B1 WITH APOPTOSIS OF VIRAL MYOCARITIS IN MOUSE |
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| Qian Shujuan
Keshan Disease Institute,Harbin Medical University.THE RELATION OF EXPRESSION OF TGF-B1 WITH APOPTOSIS OF VIRAL MYOCARITIS IN MOUSE[J].Chinese Journal of Control of Endemic Disenaces,1998,13(2):75-77. |
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| Authors: | Qian Shujuan
Keshan Disease Institute Harbin Medical University |
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| Abstract: | In the experiment Viral myocarditis (VMC) in BALB/c mouse was obtained by Coxsackie virus-B3m (CVB3m) that was inoculated into abdominal cavity. The rate of VMC was 93. 33% after 9 days of virus infection. The apoptosis(76. 67%) and expression of TGF -B1(73. 33%)found in the cell smear of myocardium of infected mouse by TdT/dvTp Nick End Labelling and immunohistochemical method. The rusults showed apoptosis may participate in occurrence and development of VMC ,and that TGF - B1 may participated in abjustment of apoptosis of VMC. |
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| Keywords: | TGF- B1 Virus Myocarditis Apoptosis |
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