| 伊贝沙坦对早期糖尿病肾病患者尿转化生长因子β_1的影响 |
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| 引用本文： | 冯毅,粱干雄. 伊贝沙坦对早期糖尿病肾病患者尿转化生长因子β_1的影响[J]. 现代医院, 2006, 6(11): 16-17 |
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| 作者姓名： | 冯毅 粱干雄 |
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| 作者单位： | 中山市人民医院,广东,中山,528400 |
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| 摘 要： | 目的观察血管紧张素Ⅱ受体拮抗剂(ARB)伊贝沙坦对早期糖尿病肾病患者尿转化生长因子β1(TGF-β1)排泄的影响,探讨其治疗糖尿病肾病的可能机理。方法72例早期糖尿病肾病患者被随机分为对照组(n=34)和伊贝沙坦组(n=38),治疗12周后测定两组治疗前后尿白蛋白排泄率(UAER)、尿TGF-β1的水平。结果伊贝沙坦组UAER、尿TGF-β1水平均有明显下降。结论伊贝沙坦对糖尿病肾病有保护作用,其机理可能与下调肾脏局部尿TGF-β1水平有关。
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| 关 键 词： | 糖尿病肾病 转化生长因子β1 伊贝沙坦 |
THE INFLUENCE OF IRBESARTAN ON URINARY TRANSFORMING GROWTH FACTOR-β1 IN EARLY DIABETIC NEPHROPATHY |
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| FENG Yi,LIANG Ganxiong. THE INFLUENCE OF IRBESARTAN ON URINARY TRANSFORMING GROWTH FACTOR-β1 IN EARLY DIABETIC NEPHROPATHY[J]. Modern Hospital, 2006, 6(11): 16-17 |
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| Authors: | FENG Yi LIANG Ganxiong |
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| Abstract: | Objective To observe the influence of irbesartan on urinary transforming growth factor-beta1(TGF-β_1) in early diabetic nephropathy and explore their therapeutic mechanism. Methods Seventy-tow type 2 diabetic patients with early diabetic nephropathy were randomly divided into control group and irbesartan treatment group. Urinary albumin excretion and urinary TGF-β_1 was measured. Results Urinary albumin excretion and urinary TGF-β_1 levels in irbesartan treatment group were significantly decreased after 12 weeks treatment. Conclusion Irbesartan have renoprotective effect in patients with early diabetic nephropathy. The decrease of TGF-β_1 concentration in renal tissue may be a mechanism for this action. |
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| Keywords: | Diabetic nephropathy Transforming growth factor - Betal Irbesartan |
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