MDSC在自身免疫疾病中的作用

髓系抑制细胞（Myeloid derived suppressor cells，MDSC）是具有抑制功能的髓系来源的细胞群。在自身免疫疾病中，MDSC显著增多，并在体外有抑制功能，然而在体内研究中，MDSC的研究存在争议。最新研究发现具有抑制功能的MDSC的显著增多并不能有效缓解自身免疫疾病，而且在某些情况下甚至促进疾病的进展。因此，MDSC在自身免疫疾病的作用有待进一步研究。本文根据已有文献，综述了MDSC在不同的自身免疫疾病中的改变及机制。

Role of myeloid derived suppressor cells in autoimmune disease

Myeloid-derived suppressor cells (MDSC) are a bone marrow-derived heterogeneous cell population with immunosuppressive activityAlthough there is convincing evidence that autoimmune diseases are associated with MDSC expansion,controversies remained regarding the role of MDSCs in controlling autoimmune responses.Recent studies have shown that the expansion of MDSCs,which are capable of inhibiting effector cell function in vitro,does not always lead to alleviation of autoimmune diseases,and in some cases paradoxically exacerbates the disease progression.This review summarizes recent insights into the role of MDSCs in the development of autoimmune responses and the potential of using MDSCs for the treatment of autoimmune diseases.