含幽门螺杆菌特异性抗体牛奶清除幽门螺杆菌效果的临床随机试验

目的:比较观察抗幽门螺杆菌抗体牛奶根除幽门螺杆菌的效果。方法:用4 株幽门螺杆菌(1 株为标准菌株,3 株为本地流行菌株)免疫奶牛,制备出抗幽门螺杆菌抗体牛奶。本次试验共筛选148 例患者,C-14 呼气试验阳性的患者为72 例,最后符合入选标准的为39 例,将符合标准的患者随机分为试验组和对照组,分别为21 例和18 例,试验组饮用含特异性幽门螺杆菌抗体的牛奶,对照组饮用普通牛奶,连续饮用2 个月后,观察结果。结果:试验组的21 名对象中,9 人C-14 呼气试验转为阴性,10 人降低。有效清除率达42.86%,而对照组未有清除,两组清除率有统计学意义(P =0.005,P<0.05)。结论:抗幽门螺杆菌抗体牛奶具有多克隆性和很高的效价,能够有效清除胃内幽门螺杆菌。

Clearance effect of milk containing anti-Helicobacter pylori specific antibody:a randomized clinical trial

Objective:To compare and observe the different clearance effect of milk containing anti-Helicobacter pylori specific Antibody.Methods: Four H.pylori strains were used to immune dairy cows to obtain milk containing anti-Helicobacter pylori specific antibody,of which,one was standardized strain and the other three were locally epidemic.Totally 148 people were screended,in which 72 were C-14 urea breath test positive,finally 39 meet the criteria.They were divided into two groups,the test group contained 21 subjects,were treated milk containing anti-Helicobacter pylori specific antibody;the 18 subjects in control group with common milk.The study was continued for 2 months.Results: Conducting the C-14 urea breath test,9 subjects in test group were negative,but no one was changed in control group.The effective clearance rate of the test group was 42.86%,and there was no effective clearance in the control group,so there was significant difference in the two groups(P =0.005,P<0.05).Conclusion: The milk containing anti-Helicobacter pylori specific antibody is polyclonal and has higher valence,and could clear H.Pylori effectively.