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Anti-secretory and anti-ulcer activities of some new 2-(2-pyridylmethyl-sulfinyl)-benzimidazoles
Authors:Enzo Cereda   Marco Turconi   Antoine Ezhaya   Elio Bellora   Alessandro Brambilla   Ferdinando Pagani  Arturo Donetti
Affiliation:1. Center for Environmentally Beneficial Catalysis, University of Kansas, Lawrence, KS 66047, United States;2. Department of Chemistry, Iowa State University, Ames, IA 50011, United States;1. Key Laboratory of Structure-Based Drugs Design and Discovery (Ministry of Education), School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China;2. Shanghai Green Valley (Benxi) Pharmaceutical Co. Ltd., Benxi 117004, China;1. Faculty of Pharmaceutical Sciences of Ribeirão Preto – USP, Av. do Café S/N, CEP 14040-903 Ribeirão Preto, SP, Brazil;2. Istituto di Biostrutture e Bioimmagini, CNR, via Mezzocannone 16, I-80134 Napoli Italy;1. Division of Gastroenterology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, ROC;2. Department of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan, ROC;3. School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC;4. Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan, ROC;5. Department of Nutrition, China Medical University, Taichung, Taiwan, ROC
Abstract:A series of substituted sulfinyl benzimidazoles were prepared and tested for gastric anti-secretory activity. Following initial screening, two compounds were tested for anti-ulcer activity. The new compounds showed pharmacological properties different from those of omeprazole 1, since they proved to be weak anti-secretory agents displaying non-specific anti-ulcer activity. Some structural requirements for optimum activity were elucidated.
Keywords:gastric anti-secretory activity   anti-ulcer activity   sulfoxides   benzimidazole sulfoxides   pyridylmethyl sulfoxides
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