三七提出物对心脏的药理作用

三七绒根提取物“76017”(简称17号)按1∶20000的浓度加入灌流液中,能增加离体豚鼠心脏冠脉流量。搏动心脏用17号后,冠脉流量增加84.04%,同时心肌收缩力增强,但心率变化不大;在用垂体后叶素收缩冠脉的基础上,用17号灌流,冠脉流量增加83.78%;纤颤心脏用17号灌流,冠脉流量增加65.06%。麻醉犬冠状静脉窦流出量测量。经十二指肠投予17号100mg/kg,冠脉流量增加57.03%,并能持续3小时以上,同时呈现心率减慢和血压降低。血氧测定结果,在冠脉流量增加高峰期,心肌耗氧量增加64.03%。心肌匀浆耗氧量测定。0.1%的17号抑制以丙酮酸为底物之耗氧量,增加以琥珀酸为底物之耗氧量。在实验性心肌梗塞模型上,静脉注入17号10mg/kg,未见到对心肌缺血性损害有保护作用,静脉注入心得安0.5 mg/kg,则有明显的保护作用。

PHARMACOLOGICAL EFFECTS OF AN EXTRACT OF PANAX NOTOGIENSENG (BURK.) F H CHEN ON THE HEART

A total extract (named number 17) was isolated from the fibrous root of Panax notogienseng (Burk.) F H chen by the Yunnan Medicinal Institute. The present paper reports the experimental results of this extract on the heart.In perfused isolated hearts of guinea pigs, number 17 can increase the coronary blood flow, an increase of 84.04% on normal beating hearts was noted With an inotropic effect. However, no obvious change in heart rate was noted. The increase on fibrillating hearts reached only 65.06%. The decrease of coronary flow induced by pituitrin in beating hearts of guinea pigs was converted to an increase of 83.78% by perfusion of number 17.The blood flow of the coronary venous sinus was measured by an inserted pipe in open-chest dogs. Number 17 increased the coronary flow to 57.03% by injection into the duodenum and lasted for over 3 hours, associated with decrease of heart rate and fall of arterial blood pressure.Myocardial oxygen consumption was analysed by Roughton-Scholander method and calculated from blood samples withdrawn from the femoral artery and the coronary venous sinus. It was found that number 17 increased the myocardial oxygen consumption to 64.30%.The oxygen consumption of myocardial homogenate of rats was studied by Warburg's manometric method. When pyruvate was used as the substrate, number 17 inhibited the oxygen consumption but increase oxygen consumption if succinate was used as the substrate.According to Maroko's method, studies were carried out in anesthetized dogs. The S-T segment elevation on epicardial electrocardiogram was used as an index of myocardial ischemic injury on experimental coronary artery occlusion. The experimental results indicate that number 17 had no protection for myocardial ischemic injury, while propranolol protected it significantly.