通冠胶囊对冠心病经皮冠脉介入术后患者凝血纤溶系统的影响

目的探讨通冠胶囊对冠心病经皮冠脉介入术(PCI)后患者体内凝血一纤溶系统的影响及其作用机制。方法采取前瞻、随机、对照的方法，观察通冠胶囊结合西药组(简称治疗组，26例)和西药组(简称对照组，26例)对冠心病PCI术后患者凝血纤溶相关指标：组织型纤溶酶原激活物(t—PA)、纤溶酶原活化剂抑制物1(PAI—1)、血友病因子(vWF)、抗凝血酶Ⅲ(AT-Ⅲ)、纤维蛋白原(FIB)的影响、结果两组治疗后较治疗前各指标均显著改善(P＜0．05)。治疗后治疗组AT-Ⅲ、t-PA较对照组显著升高(P＜0.01)，PAI-1在治疗1个月后两组比较差异无显著性(P＞0．05)，而治疗3个月后治疗组低于对照组(P＜0.05)，vWF在治疗1、3个月后两组比较差异无显著性，FIB在治疗1、3个月后治疗组显著低于对照组(P＜0.01)。结论通冠胶囊可能通过提高体内AT-Ⅲ、t-PA水平，降低FIB、PAI-1水平来改善冠心病患者介入术后高凝状态，调节体内凝血一纤溶系统平衡。

Effect of Tongguan Capsule on Coagulant and Fib rinolysis System in Patients with Coronary Heart Disease after Percutaneous Coro nary Intervention

OBJECTIVE: To explore the effect and mechanism of Tongguan capsule (TGC) on coagulant and fibrinolysis system in patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI). METHODS: Adopting the prospective, randomized controlled method to observe the coagulant-fibrinolysis related indexes, including tissue plasminogen activator (t-PA), plasminogen activator inhibitor 1 (PAI-1), von Willebrand factor (vWF), antithrombin II (AT-III) and fibrinogen (FIB), in CHD patients after PCI, there were 26 patients in the treated group treated by TGC with Western medicine and 26 in the control group treated by Western medicine alone. RESULTS: After treatment, all the indexes were improved in both groups (P < 0.05). As comparison between the two groups, AT-III and t-PA were higher in the treated group than those in the control group; PAI-1 levels showed insignificant difference at 1 month after treatment, but at 3 months after treatment, it was significantly lower in the treated group (P < 0.05); vWF showed no significant difference either at 1 or at 3 months after treatment; and FIB was lower in the treated group both at 1 and 3 months after treatment (P < 0.01). CONCLUSION: TGC could improve the hypercoagulant status and adjust the balance between coagulant-fibrinolysis system of CHD patients after PCI by increasing AT-III and t-PA levels, and lowering FIB and PAI-1 levels in the body.